Can we hire a car in Ragusa di Marina Silicy and drop off at Bari Airport?
Just insert those 2 locations when you make your search and don't forget to tick the box "Return to a different location".
If it is possible the website will show results! But I am sure from Ragusa di Marina no cars are available at all.
Choose Ragusa only (not Marina) and you will see available cars with drop off at Bari Airport. Based on your search criteris I can see Avis and Budget who do accept one way to Bari Airport.